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Other important adverse effects include acute pancreatitis (presenting as severe, persistent abdominal pain radiating to the back), gallbladder disease , and acute kidney injury , particularly in the context of severe gastrointestinal side effects leading to dehydration
The calcium-binding affinity of S100 proteins is low in the absence of target proteins, but the affinity is significantly increased by several orders of magnitude in the presence of specific target proteins ( Figure 1 The 3D structures of S100 protein family have been resolved in three different states: Ca 2+ -free apo state, bound to Ca 2+ and bound to its target protein ( Because of multiple functions of the S100 proteins, many diseases, including psoriasis, are associated with altered expression levels of S100 proteins
It is synthesized for research use to capitalize on its unique pharmacokinetic profile
Kong, A
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